| Citation | Garcia-Martinez J, Delgado-Ramos L, Ayala G, Pelechano V, Medina DA, Carrasco F, Gonzalez R, Andres-Leon E, Steinmetz L, Warringer J, Chavez S, Perez-Ortin JE . The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons Nucleic Acids Res, 2016. |
| PubMed ID | 26717982 |
| Short Description | Genomic Run On (GRO): determination of the nascent transcriptional rates and mRNA levels in several yeast mutants. |
| # of Conditions | 18 |
Full Description
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In order to maintain the appropriate level of mRNA it is necessary coordinate simultaneously all the steps along the mRNA life cycle. It has been shown that several factors act in the regulation of gene expression as global coordinators. Thus, some kind of information is transferred from the nucleus to the cytoplasm, imprinted in the mRNA. In this way, it is conceivable the existence of mechanisms that ensure the balance between mRNA synthesis and degradation through the information flow from the cytoplasm to the nucleus and vice versa, as a crosstalk among both process to ensure the proper mRNA homeostasis in the cell. more... |
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