The tags were selected based on the areas of biology investigated in the associated publications. These tags comprise a controlled vocabulary (CV) of terms synthesized and defined to cover the range of perturbations employed in the microarray experiments. These perturbations include chemical treatments, alterations in nutritional conditions, challenge with physical insult and/or changes in the genetic background due to mutation. The tags provide a means of selecting and grouping datasets based on the perturbation(s).

CV term name	Definition
amino acid metabolism	The cellular reactions and pathways used in the biosynthesis and catabolism of amino acids.
amino acid utilization	Utilization of different amino acids, combinations of amino acids, or altered levels of amino acids (e.g. amino acid limitation) during nutritional shifts.
carbon utilization	Utilization of different carbon sources, or altered quantities of the same carbon source (e.g. carbon limitation) using nutritional shifts.
cell aging	Progression of a cell from its inception to the end of its lifespan, including replicative aging (number of cell divisions a cell undergoes before dying) and chronological aging (number of days a culture remains viable in stationary phase).
cell cycle regulation	Modulation of the rate or extent of progression through the cell cycle.
cell morphogenesis	Changes in the size or shape of a cell during vegetative growth, or during developmental processes such as conjugation or filamentation.
cell wall organization	The organization and biogenesis of the cell wall from constituent parts and the response to cell wall stress.
cellular ion homeostasis	Processes involved in the maintenance of an internal steady state of ions within the cell.
chemical stimulus	Changes in the state or activity of yeast cells as a result of a chemical stimulus.
chromatin organization	Specification, formation and/or maintenance of the physical structure of eukaryotic chromatin via nucleosomes, including chromatin remodeling.
cofactor metabolism	The cellular reactions and pathways used in the biosynthesis and catabolism of cofactors.
diauxic shift	The switch from rapid fermentative growth in the presence of a rich carbon source to slower exponential growth by aerobic respiration using ethanol once the preferred carbon source has been exhausted.
DNA damage stimulus	Changes in the state or activity of yeast cells as a result of treatment with a DNA damaging stimulus.
evolution	The change over time in inherited trait(s) within a population of cells either in the absence or presence of selective forces.
fermentation	The conversion of carbohydrates to carbon dioxide and alcohol under low oxygen or anaerobic conditions.
filamentous growth	A developmental process triggered by nutritional deprivation in which yeast cells grow in a threadlike, filamentous shape, including invasive and pseudohyphal growth.
heat shock	Changes in the state or activity of yeast cells as a result of a temperature stimulus above the optimal temperature.
histone modification	Modification of amino acid residue(s) within a histone protein, by reversible processes including methylation, acetylation and ubiquitionation.
lipid metabolism	The processes involved in the biosynthesis and degradation of lipids.
mating	The process by which mating pheromone causes yeast cells to form a short conjugation tube and fuse resulting in the union of cellular and genetic information and formation of a zygote.
metal or metalloid ion stress	Changes in the state or activity of yeast resulting from the addition or deprivation of a metal ion or metalloid and the impact of mutations on this cellular stressor.
mitotic cell cycle	An ordered series of events, grouped by phase (G1, S, G2, and M) where chromosomal DNA is replicated and then segregated into daughter cells.
mRNA processing	Processes involved in the conversion of a primary transcript into one or more mature mRNA(s) prior to translation.
nitrogen utilization	Utilization of different nitrogen sources, or altered quantities of the same nitrogen source (e.g. nitrogen limitation) using nutritional shifts.
nutrient utilization	Alterations in the quality and/or quantity of nutrients during nutritional shifts or nutritional limitation, other than simple alterations in carbon source, nitrogen source, phosphate source, sulfur source, or amino acids.
osmotic stress	Changes in the state or activity of yeast as a result of a treatment that increases (hyperosmotic) or decreases (hypoosmotic) the concentration of solutes around a cell.
oxidative stress	Changes in the state or activity of yeast cells as a result of exposure to reactive oxygen species, such as hydrogen peroxide (H2O2).
oxygen level alteration	Changes in the state or activity of yeast as a result of a stimulus reflecting an increase, decrease or absence of oxygen.
phosphorus utilization	Utilization of different phosphate sources, or altered quantities of the same phosphate source (e.g. phosphate limitation) using nutritional shifts.
protein dephosphorylation	Removal of phosphate group(s) from target proteins.
protein glycosylation	Modification of proteins by the addition or removal of sugar residue(s).
protein phosphorylation	The addition of phosphate group(s) to target protein(s).
proteolysis	The hydrolysis of a peptide bond(s) within a protein resulting in the breakdown of that protein.
radiation	Changes in the state or activity of yeast resulting from an electromagnetic radiation stimulus, such as gamma radiation, ionizing radiation and X-rays.
respiration	The process of generating energy through the oxidation of organic compounds with oxygen as the final electron acceptor.
response to unfolded protein	Response to treatments such as DTT, tunicamycin, heat or to mutations that activate the unfolded protein response.
RNA catabolism	Reactions and pathways that result in the breakdown of RNA.
signaling	Pathways that transmit and amplify molecular signals to activate or inhibit a cellular process or processes.
sporulation	A complex differentiation process induced by starvation that results in the production of stress resistant spores, after DNA replication and two rounds of meiosis.
starvation	Changes in the state or activity of yeast cells as a result of a removal or deprivation of one or more nutrients.
stationary phase entry	Entry into a nonproliferative state after yeast cells have exhausted nutrients that is characterized by cell cycle arrest, cell wall thickening, accumulation of reserve carbohydrates, and acquisition of thermotolerance.
stationary phase maintenance	Maintenance of a nonproliferative state induced by starvation and characterized by cell cycle arrest, cell wall thickening, accumulation of reserve carbohydrates, and acquisition of thermotolerance.
stress	Changes in the state or activity of yeast as a result of a treatment or mutation that results in stress and the associated stress response.
sulfur utilization	Utilization of different sulfur sources, or altered quantities of the same sulfur source (e.g. sulfur limitation) using nutritional shifts.
transcription	The synthesis of RNA from a DNA template by RNA polymerase, and accessory factors.
translational regulation	Modulation of the frequency, rate or extent of protein formation by translation of mRNA.
ubiquitin or ULP modification	The covalent attachment or removal of ubiquitin or ubiquitin-like proteins (ULPs) from target protein(s).
not yet curated	The dataset has not yet been assigned a tag or tags.