SPELL - S. cerevisiae

Citation	Carter GW, Prinz S, Neou C, Shelby JP, Marzolf B, Thorsson V, Galitski T. Prediction of phenotype and gene expression for combinations of mutations. Molecular systems biology, 2007.
PubMed ID	17389876
Short Description	Prediction of phenotype and gene expression for combinations of mutations.
# of Conditions	90
Full Description	Molecular interactions provide paths for information flows. Genetic interactions reveal active information flows and reflect their functional consequences. We integrated these complementary data types to model the transcription network controlling cell differentiation in yeast. Genetic interactions were inferred from linear decomposition of gene expression data and were used to direct the construction of a molecular interaction network mediating these genetic effects. This network included both known and novel regulatory influences, and predicted genetic interactions. For corresponding combinations of mutations, the network model predicted quantitative gene expression profiles and precise phenotypic effects. Multiple predictions were tested and verified.
Tags	filamentous growth