SPELL - S. cerevisiae

Citation	Rosaleny LE, Antunez O, Ruiz-Garcia AB, Perez-Ortin JE, Tordera V. Yeast HAT1 and HAT2 deletions have different life-span and transcriptome phenotypes. FEBS letters, 2005.
PubMed ID	16023114
Short Description	Yeast HAT1 and HAT2 deletions have different life-span and transcriptome phenotypes.
# of Conditions	15
Full Description	HAT-B is a yeast histone acetyltransferase composed of Hat1, Hat2 and Hif1 proteins. We demonstrate that a hat2 mutant or a hat1hat2 double mutant, but not a hat1 mutant, have an extended life-span. Transcriptome analysis shows that the single hat mutants are not very different from wild type. However, the comparison of the hat1 and hat2 transcriptomes shows that they are different. The hat1hat2 double mutant shows a transcriptional phenotype similar to that of the hat1 mutant but strongly enhanced. These results indicate that Hat2p could have additional functions in the cell to those of Hat1p.
Tags	histone modification