SPELL - S. cerevisiae

Citation	Capaldi AP, Kaplan T, Liu Y, Habib N, Regev A, Friedman N, O'Shea EK. Structure and function of a transcriptional network activated by the MAPK Hog1. Nature genetics, 2008.
PubMed ID	18931682
Short Description	Structure and function of a transcriptional network activated by the MAPK Hog1.
# of Conditions	85
Full Description	Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. To gain insight into the structure and function of these networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast. Our model reveals that the Hog1 and general stress (Msn2/4) pathways interact, at both the signaling and promoter level, to integrate information and create a context-dependent response. This study lays out a path to identifying and characterizing the role of signal integration and processing in other gene regulatory networks.
Tags	osmotic stress, stress, transcription