Citation Gasch AP,et al. Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Molecular biology of the cell, 2001.
Short Description Expression in response to DNA-damaging agents and role of the Mec1 signaling pathway (mec1, dun1 and crt1)
wildtype + 0.02% MMS (5 min) wildtype + 0.02% MMS (15 min) wildtype + 0.02% MMS (30 min) wildtype + 0.2% MMS (45 min) wildtype + 0.02% MMS (60 min) wildtype + 0.02% MMS (90 min) wildtype + 0.02% MMS (120 min) mec1 mutant + 0.02% MMS (5 min) mec1 mutant + 0.02% MMS (15 min) mec1 mutant + 0.02% MMS (30 min) mec1 mutant + 0.02% MMS (45 min) mec1 mutant + 0.02% MMS (60 min) mec1 mutant + 0.02% MMS (90 min) mec1 mutant + 0.02% MMS (120 min) dun1 mutant + 0.02% MMS (30 min) dun1 mutant + 0.02% MMS (90 min) dun1 mutant + 0.02% MMS (120 min) wildtype + gamma irradiation (5 min) wildtype + gamma irradiation (10 min) wildtype + gamma irradiation (20 min) wildtype + gamma irradiation (30 min) wildtype + gamma irradiation (45 min) wildtype + gamma irradiation (60 min) wildtype + gamma irradiation (90 min) wildtype + gamma irradiation (120 min) wildtype + mock irradiation (5 min) wildtype + mock irradiation (30 min) wildtype + mock irradiation (60 min) wildtype + mock irradiation (90 min) mec1 mutant + gamma irradiation (5 min) mec1 mutant + gamma irradiation (10 min) mec1 mutant + gamma irradiation (20 min) mec1 mutant + gamma irradiation (30 min) mec1 mutant + gamma irradiation (45 min) mec1 mutant + gamma irradiation (60 min) mec1 mutant + gamma irradiation (90 min) mec1 mutant + gamma irradiation (120 min) mec1 mutant + mock irradiation (5 min) mec1 mutant + mock irradiation (30 min) mec1 mutant + mock irradiation (60 min) wildtype + heat (20 min) mec1 mutant + heat (20 min) dun1 mutant + heat (20 min) wildtype vs. wildtype log phase - control wildtype vs. mec1 mutant - log phase (gamma irradiation time = 0 cells) mec1 mutant - log phase (MMS time = 0 cells) wildtype vs. mec1 mutant genomic DNA comparison (expt 1) wildtype vs. mec1 mutant genomic DNA comparison (reverse fluor array) wildtype vs. dun1 mutant genomic DNA crt1 mutant vs wild type (expt 1) crt1 mutant vs. wild type (expt 2) GAL-inducible ROX1 on galactose
YNL046W 0.37 0.58 0.55 0.27 -0.07 -0.55 -0.43 0.40 0.27 0.65 0.46 0.18 -0.33 -0.16 0.52 -0.34 -0.14 -0.17 0.10 -0.40 -0.77 -1.10 -0.76 0.42 -0.07 0.32 0.60 -0.05 -0.24 -0.78 -0.81 -0.56 -0.57 0.07 0.28 0.35 -0.20 0.37 -0.20 0.16 -0.72 -0.24 0.02 0.23 0.14 0.09 0.35 0.52 0.70 0.56 0.35