SPELL - S. cerevisiae

Citation	Vizoso-Vazquez A, Lamas-Maceiras M, Becerra M, Gonzalez-Siso MI, Rodriguez-Belmonte E, Cerdan ME. Ixr1p and the control of the Saccharomyces cerevisiae hypoxic response. Applied microbiology and biotechnology, 2012.
PubMed ID	22189861
Short Description	Ixr1p and the control of the Saccharomyces cerevisiae hypoxic response.
# of Conditions	12
Full Description	In Saccharomyces cerevisiae, adaptation to hypoxia/anaerobiosis requires the transcriptional induction or derepression of multiple genes organized in regulons controlled by specific transcriptional regulators. Ixr1p is a transcriptional regulatory factor that causes aerobic repression of several hypoxic genes (COX5B, TIR1, and HEM13) and also the activation of HEM13 during hypoxic growth. Analysis of the transcriptome of the wild-type strain BY4741 and its isogenic derivative Deltaixr1, grown in aerobic and hypoxic conditions, reveals differential regulation of genes related not only to the hypoxic and oxidative stress responses but also to the re-adaptation of catabolic and anabolic fluxes in response to oxygen limitation. The function of Ixr1p in the transcriptional regulation of genes from the sulfate assimilation pathway and other pathways producing alpha-keto acids is of biotechnological importance for industries based on yeast-derived fermentation products.
Tags	oxygen level alteration