| Citation | Golla U, Joseph D, Tomar RS . Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model. Sci Rep, 2016. |
| PubMed ID | 27734932 |
| Short Description | Genome-wide expression profiling after Valproic acid treatment in Saccharomyces cerevisiae |
| # of Conditions | 4 |
Full Description
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Valproic acid (VA) is a small-chain branched fatty acid, widely used as anticonvulsant, and mood stabilizer to treat psychiatric illness. Valproic acid is also known to inhibit the histone deacetylases (HDACs), which makes it as a potent antitumor agent in alone or in combination with other cytotoxic drugs. Beside its conventional activities, valproic acid reported to have much broader, complicated effects and affect many complex physiological processes. more... |
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