SPELL - S. cerevisiae

Citation	Sariki SK, Sahu PK, Golla U, Singh V, Azad GK, Tomar RS . Sen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiae FEBS J, 2016.
PubMed ID	27718307
Short Description	Comparative transcriptome analysis of basal gene expression in Wild-type and Sen1_N mutant of Saccharomyces cerevisiae
# of Conditions	4
Full Description	In Saccharomyces cerevisiae, Sen1 is a 252-kDa, nuclear superfamily-1 RNA/DNA helicase that encoded by an essential gene SEN1 (Senataxin). It is an important component of the Nrd1p-Nab3p-Sen1p (NRD1) complex that regulates the transcriptional termination of most non-coding and some coding transcripts at RNA polymerase pause sites. Sen1 specifically interacts with Rnt1p (RNase III), an endoribonuclease, and with Rpb1p (Rpo21p), a subunit of RNA polymerase II, through its N-terminal domain (NTD), which is a critical element of the RNA-processing machinery. more...
Tags	disease, DNA replication, recombination and repair