| Citation | Klecker T, Wemmer M, Haag M, Weig A, Bockler S, Langer T, Nunnari J, Westermann B . Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast Sci Rep, 2015. |
| PubMed ID | 26669658 |
| Short Description | MDM33 overexpression suppressor screen |
| # of Conditions | 24 |
Full Description
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We performed a genome-wide screen for genetic MDM33 interaction partners. Using the opposite approach of the well known synthetic dosage lethality (screening for deletion strains in which a non-toxic overexpression is associated with a synthetic growth arrest) we screened the whole genome for genes that are essential for the growth arrest associated with MDM33 overexpression. In a pooled collection of viable haploid gene deletion mutants, of which each is tagged with a unique identifying molecular bar-code sequence, the overexpression of MDM33 was induced using a galactose responsive promotor. more... |
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